Anti-ASGM1, NK Cell, Activated T Cell, and Graft-vs-Host Disease
نویسندگان
چکیده
منابع مشابه
Anti-ASGM1, NK cell, activated T cell, and graft-vs-host disease.
To the Editor: In 1978, Korngold et al demonstrated that removal of "all mature" T lymphocytes by anti-Thy-1.2 and complement was very effective in preventing the development of significant graft-vs-host disease (GVHD) in mice [1]. However, implementation of this strategy in patients using OKT3 failed to achieve similar impressive results [2]. Having learned of the work of Lopez who demonstrate...
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CD3-negative NK cells are granular lymphocytes capable of producing inflammatory cytokines and killing malignant, infected, or stressed cells. We have recently observed a new role for NK cells in the control of the proliferation of CD4 T cells under persistent antigenic stimulation. Monoclonal anti-male CD4 T cells transferred into Rag2-/- male recipients did not expand or were rapidly eliminat...
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Hematopoietic stem cell transplantation (HSCT) is often the only curative treatment for a wide variety of hematologic malignancies. Donor selection in these diseases is crucial, given that transplanted cells can mediate not only the desired graft-versus-leukemia effect but also graft-versus-host disease (GVHD). Here, we demonstrate that in the absence of NKp46, a major killer receptor expressed...
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Background: Bone marrow transplantation (BMT) is considered as a curative therapy for a broad range of diseases. However, complications such as relapse and graft versus host disease (GVHD) may be observed following BMT. Chimerism analysis serves as a reliable indicator of transplant outcome. Complete chimerism refers to the complete replacement of hematopoietic system by donor cells, while mixe...
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BACKGROUND Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy with proven efficacy in the management of hematologic malignancies. However, it is complicated by the syndromes of acute and chronic graft-vs-host disease (GVHD). METHODS A narrative review is provided to summarize major biologic insights into the pathogenesis of these immune-mediated disorders, a...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1989
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12277550